What Are the Causes of Diastolic Dysfunction?

The primary causes of diastolic dysfunction include chronic high blood presssure, aortic stenosis, coronary artery disease, restrictive cardiomyopathy and aging.

In restrictive cardiomyopathy, abnormal cells, protein, or scar tissue causes infiltration of the heart muscle and it is made stiff. Amyloidosis is the most common cause of restrictive cardiomyopathy in which a disease in which protein-like substance is deposited within the body’s tissues. Sarcoidosis and hemochromatosis are other causes for restrictive cardiomyopathy. The effect of aging is yet to be understood clearly if it alone causes stiffening of the ventricles.